Antisense Technology
Schizophyllan shows promise for transporting antisense oligonucleotides
Published in Gene Therapy Weekly, March 25th, 2004
"Schizophyllan is a natural beta-(1 --> 3)-D-glucan existing as a triple helix in water and as a single chain in dimethylsulfoxide (DMSO), respectively. As we already reported, when some homo-phosphodiester polynucleotide (for example, poly(dA) or poly(C)) is added to the schizophyllan/DMSO solution and subsequently DMSO is exchanged for water, the single chain of schizophyllan forms a complex with the polynucleotide. Furthermore, we have already demonstrated that one of the potential applications of this novel complex is an antisense-oligonucleotide (AS ODN) carrier," researchers in Japan...
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Source: Gene Therapy Weekly (2004-03-25)
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