DNA Vaccine
Altering conditions of DNA immunization allows control of immune response
Published in Gene Therapy Weekly, April 1st, 2004
According to published research from the United States, "DNA immunization by intramuscular (IM) injection induces Th1 responses, whereas gene gun (GG) immunization into the skin stimulates Th2 responses. Three ovalbumin (OVA) cDNA constructs, in which OVA is cytoplasmic (CYT), secreted (SECR), or transmembrane (TM), were compared in immunization studies using intramuscular injection or biolistic bombardment of the skin."
"Gene gun immunization with OVA-CYT or OVA-TM led to strong OVA-specific CTL...
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Source: Gene Therapy Weekly (2004-04-01)
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