Oncogenesis
Protein tyrosine phosphatase gamma is a tumor suppressor gene in breast cancer
Published in Gene Therapy Weekly, April 1st, 2004
"Protein tyrosine phosphatase gamma (PTPgamma) is a member of the receptor-like family of tyrosine phosphatases and has been implicated as a tumor suppressor gene in kidney and lung cancers. Based on our previous findings, we hypothesize that PTPgamma is a potential estrogen-regulated tumor suppressor gene in human breast cancer. To examine the effects of PTPgamma on growth of MCF-7 human breast cancer cells and compare the estrogenic responses of human breast cells with different PTPgamma expression levels, we established several stably transfected MCF-7 cell lines expressing different...
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Source: Gene Therapy Weekly (2004-04-01)
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