Vector Development
Silk-elastin-like hydrogels convey genes to human cancer cells
Published in Gene Therapy Weekly, April 1st, 2004
"The objectives of this study were to evaluate:
i) the influences of hydrogel geometry, DNA molecular weight, and DNA conformation on DNA release from a silk-elastin-like protein polymer (SELP) hydrogel,
ii) the bioactivity and transfection efficiency of encapsulated DNA over time in vitro,
iii) the delivery and transfection of a reporter gene in a murine model of human breast cancer in vivo, and
iv) the in vitro release and bioactivity of adenovirus containing the green fluorescent protein (gfp) gene as a marker of gene...
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Source: Gene Therapy Weekly (2004-04-01)
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