Cell Biology
Integrin-linked kinase regulates VEGF-induced vascular morphogenesis
Published in Gene Therapy Weekly, April 1st, 2004
According to a study from Japan, "integrin-linked kinase (ILK) is one of the signaling moieties that interact with the cytoplasmic domains of integrin beta1 and beta3 subunits. Integrin-mediated outside-in signals cooperate with vascular endothelial growth factor (VEGF) receptor to promote morphological changes, cell proliferation, and motility in endothelial cells. In this report we demonstrate that VEGF-induced vessel morphogenesis of human umbilical vein endothelial cells (HUVEC) was inhibited by the transfection of a dominant negative, kinase-deficient ILK (ILK-KD), as well as by treatment with...
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Source: Gene Therapy Weekly (2004-04-01)
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