Gene Transfer
Arginine-rich peptides stabilize polyplexed DNA to improve transduction
Published in Gene Therapy Weekly, April 8th, 2004
"In this study, we investigated to what extent the stability and transduction capacity of polyplexed DNA can be improved by optimizing the condensing peptide sequence. We have synthesized a small library of cationic peptides, at which the lysine/arginine ratio and the cation charge were varied. All peptides were able to compact DNA, at which polyplexes of short lysine-rich sequences were considerably larger than those of elongated or arginine-rich peptides (GM102 and GM202)," according to recent research from The Netherlands.
"In addition, the arginine-rich peptides GM102 and...
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Source: Gene Therapy Weekly (2004-04-08)
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