Neuroscience
Chimeric peptides look promising for delivering genes to select neurons
Published in Gene Therapy Weekly, April 8th, 2004
According to a study from Singapore, "one obstacle to effective gene therapies for neurological disorders lies in the cell-type diversity of the nervous system, making it difficult to direct gene delivery vectors to specific types of cells. To meet this challenge, we have developed a recombinant peptide-based gene delivery vector that targets nerve growth factor (NGF) receptors. The peptide comprises a cell-targeting domain derived from the NGF hairpin motif containing loops 1 and 2 linked to a DNA-binding domain composed of SPKR repeats."
"In PC12 cells, it activated the...
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Source: Gene Therapy Weekly (2004-04-08)
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