Recombinant Research
Local gene therapy and immunosuppression promote osteoinductive activity
Published in Gene Therapy Weekly, April 8th, 2004
"We have previously utilized a human bone morphogenetic protein-2 (BMP-2)-expressing recombinant adenoviral vector (AxCAOBMP-2) for osteoinductive gene therapy in rats. However, immunosuppression is essential for osteoinduction by AxCAOBMP-2 and this is one of the major impediments to its clinical use. Injection of AxCAOBMP-2 together with the immunosuppressant FK506 made it possible to markedly reduce the dose of the immunosuppressive agent and still induce ectopic bone reliably," investigators in Japan report.
"We injected AxCAOBMP-2 and FK506 into the right calf muscle of...
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Source: Gene Therapy Weekly (2004-04-08)
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