Vector Development
FV-based SIN vectors could potentially produce replication-competent revertants
Published in Gene Therapy Weekly, April 8th, 2004
According to a study from Germany, "self-inactivating (SIN) retroviral vectors based on feline foamy virus (FFV) were constructed and analyzed. The FFV SIN vectors were devoid of the core FFV long terminal repeat promoter plus upstream sequences but contained all structural and regulatory genes. This design allowed sensitive detection of replication-competent revertants (RCRs)."
"The FFV SIN vectors efficiently transduced the green fluorescence protein into recipient cells. However, RCRs appeared after serial passages of transduced cells. In all RCR clones analyzed,...
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Source: Gene Therapy Weekly (2004-04-08)
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