Endocrinology
PPAR-delta regulates intestinal adenoma growth in mice
Published in Gene Therapy Weekly, April 22nd, 2004
Apc(min) mice, which are predisposed to intestinal polyposis, were treated with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta)," wrote investigators at Vanderbilt University.
"Exposure of Apc(min) mice to the PPAR-ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm," R.A. Gupta and colleagues reported.
"Our results implicate PPAR-delta...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2004-04-22)
More Articles from Gene Therapy Weekly
- Gastroenterology
Inducible nitric oxide synthase sensitizes colorectal cancer to radiation - Gynecology
The ceruloplasmin promoter shows an affinity for ovarian tumors - Biological Therapy
Silenced clusterin-apolipoprotein J gene causes cancer cells to implode - Gene Transfer
A new cleavage product gives real-time information about transgene activity - Immunology
Gene therapy in a murine multiple sclerosis model corrects disease - Pediatric Cancer
Herpes simplex virus thymidine kinase genes diminish nearby neuroblastoma cells - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
