Charcot-Marie-Tooth Disease

Genetic basis of hereditary nerve disorder revealed

Published in Gene Therapy Weekly, April 29th, 2004

A major form of one of the most prevalent inherited neurological disorders in humans, Charcot-Marie-Tooth disease (CMT), stems from an abnormality in the cellular powerhouses, or mitochondria, that fuel the nerves required for muscle control, suggest new findings by neurogeneticists at the Duke Center for Human Genetics and their international colleagues.

The unexpected discovery could open new research pathways to understanding an array of diseases of the peripheral nervous system, as well as treatments for CMT, the researchers said.

In seven families with a form of the degenerative nerve disorder CMT type 2A, the team discovered that defects in a...

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Source: Gene Therapy Weekly (2004-04-29)

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