Bacteriology
Helicobacter pylori CagA protein variation may increase risk of gastric cancer
Published in Gene Therapy Weekly, April 29th, 2004
"Recent molecular analysis has provided the pathological actions of CagA on gastric epithelial cells. CagA is injected into epithelial cells via the type IV secretion system and undergoes tyrosine phosphorylation in the cells. In addition, translocated CagA forms a physical complex with SHP-2," wrote Takeshi Azuma in the Journal of Gastroenterology.
"There are two major CagA subtypes; the East Asian and the Western type. The East Asian CagA protein possesses stronger SHP-2 binding activity than the Western CagA. The grades of inflammation, activity of...
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Source: Gene Therapy Weekly (2004-04-29)
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