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Cancer Therapy

Radiolanthanides show promise in targeted cancer immunotherapy

Published in Gene Therapy Weekly, May 6th, 2004

A series of radiolanthanides have significant antitumor effects in mice.

"149Pm, 166Ho, and 177Lu possess a range of half-lives and alpha-beta- energies for targeted radiotherapy of cancer," scientists in the United States explained.

"149Pm-. 166Ho-, and 177Lu-DOTA-biotin were pretargeted to LS174T colorectal tumors in nude mice with CC49 scFvSA antibody-streptavidin fusion protein," in a study conducted by M.R. Lewis and colleagues at the University of Missouri.

"Tumor uptakes of 149Pm (22.9% ID/g), 166Ho (30.2% ID/g),...

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