Myocardial Infarction
Dual gene transfer stimulates angiogenesis after a heart attack
Published in Gene Therapy Weekly, May 6th, 2004
"Therapeutic effects of combination of angiogenic growth factors for the treatment of ischemia after myocardial infarction are largely unknown. Plasmids expressing basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF-BB) or their combination with a 1:1 mass ratio were injected into hearts with 7-day-old myocardial infarction. Hearts were harvested after 1 and 4 weeks after gene transfer," scientists in Sweden report.
"The major findings in this chronic myocardial infarction model were that bFGF, PDGF-BB and their combination all had a more pronounced...
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Source: Gene Therapy Weekly (2004-05-06)
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