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Gene Therapy

HIV/gammaretrovirus-based STAR vector packaging system evaluated

Published in Gene Therapy Weekly, May 6th, 2004

A novel gene therapy vector system based on gammaretrovirus-psuedotyped HIV has been evaluated.

Scientists in England "recently described a novel, stable human immunodeficiency virus type 1 (HIV-1) vector packaging system, STAR. High-titer HIV-1 vectors bearing gammaretrovirus envelopes (Env) are continuously produced from STAR cells."

In their subsequent study, B.L. Strang and coauthors at University College London compared "the properties of such vectors, with the amphotropic murine leukemia virus (MLV-A) Env, a modified gibbon ape leukemia virus (GALV) Env and two modified versions of the cat endogenous retrovirus RD114 Env, produced from STAR...

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