Vector Development
Folate receptor-targeted lipid vesicles ferry oligodeoxynucleotides to tumors
Published in Gene Therapy Weekly, May 6th, 2004
"A major problem in exploring the full potential of antisense ODN is the lack of a safe and efficient delivery system. In this study a new method has been developed that is highly efficient in encapsulating oligodeoxynucleotides (ODN) inside folate receptor (FR)-targeted lipid vesicles. ODN formulated in these vesicles were efficiently protected from degradation by mideases compared to free ODN," investigators in the United States report.
"Folate efficiently mediated intracellular delivery of ODN to KB tumor cells that overexpress FR. Delivery of epidermal growth factor...
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Source: Gene Therapy Weekly (2004-05-06)
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