Cancer Therapy
Prodrugs becoming an integral part of the drug discovery paradigm
Published in Gene Therapy Weekly, May 13th, 2004
"Prodrugs are bioreversible derivatives of drug molecules used to overcome some barriers to the utility of the parent drug molecule. These barriers include, but are not limited to, solubility, permeability, stability, presystemic metabolism and targeting limitations," wrote investigators from the University of Kansas.
"The patent literature shows a dramatic increase in numbers of prodrug patents (>2000% increase in 2002 compared to 1993), with claims for cancer treatment comprising 37% of these. This increase is largely due to the rise from North American-based multinationals...
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Source: Gene Therapy Weekly (2004-05-13)
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