Molecular Virology

Promoter activity of AVL-A LTR region related to induction of glial neoplasm

Published in Gene Therapy Weekly, May 13th, 2004

The promoter activity of the avian leukosis virus subgroup A LTR region may be related to the induction of glial neoplasm.

"So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A)." The "complete nucleotide sequence of the virus genome" was determined. "The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes," wrote investigators in Japan.

"The coding sequences were well conserved with those of replication-competent viruses, but the 3' noncoding regions including LTR were most related to those of...

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Source: Gene Therapy Weekly (2004-05-13)

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