Atherosclerosis
Apolipoprotein A-I gene transfer helps the arteries of apo E-deficient mice
Published in Gene Therapy Weekly, May 13th, 2004
According to a study from Italy, "apolipoprotein A-I (APOA-I) is the major protein component of high-density lipoproteins (HDL). It has been shown that over-expression of human APOA-I increases HDL cholesterol and decreases atherosclerosis. We constructed a helper-dependent adenoviral (HD-Ad) vector that contains the entire human APOA-I gene (hgAI).
"Intravenous delivery of 1 x 1013 viral particles/kg of this vector was followed by high levels of human APOA-I expression (up to 200 mg/dl) in the absence of detectable hepatic toxicity. We treated apo E-deficient...
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Source: Gene Therapy Weekly (2004-05-13)
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