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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . May 20th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Adverse Drug Effects - Long-term studies show transduced stem cells do not cause leukemia

Cancer Prevention - Upregulated heat shock protein 70 protects against tumor growth in mice

Diagnostics - A new semiquantitative assay explores the angiogenic potential of genes

Gene Suppression - Interleukin-12 gene therapy changes gene expression to block cancer growth

Immunology - Interleukin-12 gene therapy and 4-1BB costimulation drive melanoma eradication

Antitumor Effects - Magnaese superoxide dismutase mutant has potent antitumor effects

Atherosclerosis - P22phox augments diabetes-mediated vascular disease

Barrett Metaplasia - Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways

Bioethics - Professionals and consumers have divergent opinions about somatic gene therapy

Biomaterial - Schizophyllan encourages the long-term expression of transgenes

Brain Tumor - Epigenetic downregulation of CTMP transcription common in glioblastomas

Breast Cancer - 540 protein inhibitors promising treatments for postmenopausal breast cancer

Breast Cancer - Bcl-2 overexpression prevents Tc-99m-MIBI uptake in breast cancer cells

Breast Cancer - Brk protein tyrosine kinase therapeutic cancer target

Cancer Risk - L-myc gene polymorphism not associated with lung ADCA risk and prognosis

Cancer Therapy - Dacogen and Taxotere show synergistic activity against human carcinoma cells

Cancer Therapy - Novel 2-nitroimidazole-tethered tricyclic quinoline compounds cytotoxic

Cancer Therapy - Novel drug wrenchnolol impairs transcription of Her2 oncogene

Cancer Therapy - The recombinant disintegrin domain of metargidin diminishes tumor vessels

DNA Sequence - Human chromosome 13 DNA sequenced and analyzed

Diagnostics - Glucagon 19-29 tagging vector monitors protein levels after plasmid transfer

Diagnostics - Mammaglobin promising diagnostic marker for breast cancer

Diagnostics - Smac/DIABLO expression a novel prognostic marker of lung cancer

Drug Target - Transient receptor potential ion channels potential drug targets

Endocrinology - Taurine uptake affected by estradiol in endometrial tumor cells in vitro

Estrogen - Elucidating estrogen response genes identifies therapy risks and benefits

Estrogen Receptor - Selective estrogen receptor modulators safer alternative to traditional HRT

Fetal Medicine - F-deficient Sendai virus vector is less toxic to fetal tissue

Gene Delivery - Chitosan augments the efficacy of non-viral gene transfer

Gene Scanning - Scanning microscopy tracks transgene expression after non-viral gene delivery

Gene Transfer - Minor capsid protein IX gives adenoviral particles access to more ligands

Geriatrics - Adenoviral transfer of the VEGF gene stimulates angiogenesis in aging animals

Hypercholesterolemia - Tracer injections monitor transgene expression in hyperlipidemic rabbits

Kidney Disease - Blocked monocyte chemoattractant protein-1 deters renal fibrosis

Liver Cancer - Overexpressed L36a gene associates with hepatocellular carcinoma proliferation

Melanoma - Interleukin-2 gene therapy increases survival in mice bearing melanoma tumors

Oncogenesis - Treatment targeting oncogenes could sensitize tumors to antiangiogenic agents

Ovarian Cancer - Gene promoter hypermethylation encourages rare ovarian malignancies

Pain Medicine - Gene based therapy will provide new options for treating chronic pain

Rheumatology - Synovial fluid hampers virus mediated gene transfer to chondrocytes

Skin Cancer - Topical DNA oligonucleotide therapy reduces UV-related mutagenesis

Stem Cell Research - Adenovirus serotype 35 has a broad reconstitution capacity

Stem Cell Research - Human neural stem cell lines are stable when cultured for long periods

Survival and Mortality - High C-reactive protein marks poor outcomes after stem cell transplantation

Vector Development - Constructs containing special micelles transfect liver cells

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