Kidney Disease
Blocked monocyte chemoattractant protein-1 deters renal fibrosis
Published in Gene Therapy Weekly, May 20th, 2004
According to a study from Japan, "monocyte chemoattractant protein (MCP)-1, also termed monocyte chemotactic and activating factor (MCAF)/CCL2, plays an important role in progressive organ fibrosis. It was hypothesized that MCP-1, through its cognate receptor, CCR2, regulates the pathogenesis and is therapeutically of importance for renal fibrosis. To achieve this goal, the therapeutic efficacy and efficiency in renal fibrosis induced by a unilateral ureteral obstruction nephropathy model in mice by the blockade of MCP-1/CCR2 signaling was studied.
"The delivery of N-terminal deletion...
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Source: Gene Therapy Weekly (2004-05-20)
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