Published in Gene Therapy Weekly, May 20th, 2004
"Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O2 (radical anion)) to O2 and H2 O2 . A unique characteristic of this mitochondrial anti-oxidant enzyme is the conservation from bacteria to man of a rapidly formed product inhibited state," wrote scientists at the University of Florida.
"Using site-directed mutagenesis," an "active site mutant (H30N) of human Mn-SOD" has been generated "which exhibits significantly reduced product inhibition and increased enzymatic efficiency....
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