Barrett Metaplasia
Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways
Published in Gene Therapy Weekly, May 20th, 2004
"Mechanisms by which premalignant Barrett's metaplasia (BM) progresses to esophageal adenocarcinoma are currently being sought." The "role played by the polypeptide hormone gastrin, specifically its antiapoptotic effects through activation of protein kinase B/Akt (PKB/Akt)" was investigated. "In esophageal cell lines with low basal levels of activated PKB/Akt, phosphorylation could be induced by exogenous amidated gastrin," wrote scientists in the journal Cancer Research.
"High basal levels of activated PKB/Akt were linked to endogenous gastrin expression and were...
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Source: Gene Therapy Weekly (2004-05-20)
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