Published in Gene Therapy Weekly, May 27th, 2004
"Neuropeptide Y (NPY) inhibits seizures in experimental models and reduces excitability in human epileptic tissue. We studied the effect of long-lasting NPY overexpression in the rat hippocampus with local application of recombinant adeno-associated viral (AAV) vectors on acute kainate seizures and kindling epileptogenesis," scientists in Italy report.
"Transgene expression was significantly increased by 7 days, reached maximal expression by 2 weeks, and persisted for at least 3 months," stated C. Richichi and colleagues, Mario Negri Institute of Pharmacology Research, Department of...
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