Virology
Adenovirus vector libraries provide clues about gene and protein function
Published in Gene Therapy Weekly, May 27th, 2004
According to a study from the United States, "a method was developed to generate a complex cDNA expression library within an adenovirus type 5 (Ad5)-based vector backbone, termed AdLibrary. Construction of the AdLibrary entailed the conversion of an Ad5 genome-containing cosmid to infectious virus particles. The Ad5 genome was modified by replacing the E1A and E1B genes with a Rous sarcoma virus-driven expression cassette.
"Conversion was accomplished by liberating the viral genome by restriction enzyme digestion and transfection in HEK 293 cells, which support the growth of...
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Source: Gene Therapy Weekly (2004-05-27)
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