Angiology
Autologous vascular smooth muscle cells are a conduit for cardiac gene transfer
Published in Gene Therapy Weekly, May 27th, 2004
According to recent research from Finland, "we have developed an ex vivo gene transfer technique to rabbit arterial wall using autologous smooth muscle cells (SMCs). SMCs were harvested from rabbit ear artery, transduced in vitro with vesicular stomatitis virus G-glycoprotein pseudotyped retrovirus or feline immunodeficiency virus (FIV) and returned to the adventitial surface of the carotid artery using a periadventitial silicone collar or collagen sheet placed around the artery. Beta-galactosidase (lacZ) and human apolipoprotein E3 (apoE3) cDNAs were used as transgenes.
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Source: Gene Therapy Weekly (2004-05-27)
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