Urology
Vectors bearing the uroplakin II promoter staunch bladder cancer
Published in Gene Therapy Weekly, June 3rd, 2004
According to published research from the Peoples Republic of China, "the differential expression of the desired gene product in the target tissue is central for gene therapy. One approach is to use a tissue-specific promoter to drive therapeutic gene expression. Uroplakin II (UPII) is a urothelium-specific membrane protein.
"To investigate the feasibility of targeting gene therapy for bladder cancer, a DNA fragment of 2542-bp upstream of the UPII gene was amplified by PCR and linked to a promoterless firefly luciferase reporter gene. The transient transfection showed that the DNA...
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Source: Gene Therapy Weekly (2004-06-03)
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