Cervical Cancer

Recombinant adenovirus p53 effects cancer cell apoptosis

Published in Gene Therapy Weekly, June 17th, 2004

Oncologists in South Korea have demonstrated effective in vitro and in vivo adenovirus-mediated p53 gene transfection in cervical cancer cell lines and the resultant p53-dependent apoptosis of transfected cells.

"To evaluate anti-tumor effects of recombinant adenovirus p53, time-course p53, E6 expression, and cell growth inhibition were investigated in vitro and in vivo using cervical cancer cell lines such as CaSki, SiHa, HeLa, HeLaS3, C33A, and HT3," wrote W.S. Ahn and colleagues, Catholic University of Korea, College of Medicine.

"The cell growth inhibition was studied via cell count assay, MTT assay, and neutral red assay. After transfecting...

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Source: Gene Therapy Weekly (2004-06-17)

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