Amyotrophic Lateral Sclerosis

Gene therapy with growth factor seems promising for incurable muscle disorder

Published in Gene Therapy Weekly, June 17th, 2004

Researchers from VIB (the Flanders Interuniversity Institute for Biotechnology), led by Professor Peter Carmeliet (K.U. Leuven) have previously indicated the importance of the VEGF protein in amyotrophic lateral sclerosis (ALS), on the basis of genetic studies.

In cooperation with Oxford BioMedica, an Oxford-based biotech company, a new study of the VIB researchers indicates that gene therapy with VEGF appears to be one of the most promising therapies. By administering the gene that produces VEGF in the nerve trajectory of ALS mice, the researchers were able to slow down the development of the illness and increase their life expectancy by 30% - the largest therapeutic...

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Source: Gene Therapy Weekly (2004-06-17)

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