DNA Vaccine
Inoculation of plasmid DNA induced expression of LacZ gene
Published in Gene Therapy Weekly, June 24th, 2004
"DNA immunization induces systemic humoral and cellular immune responses to the antigen encoded by cDNA in a plasmid DNA. In the present study, a plasmid DNA encoding cDNA of beta-galactosidase (beta-gal), pCAGGS-lacZ, was inoculated intramuscularly to a healthy dog in order to evaluate location and duration of the gene expression. On day 7, the plasmid DNA was found by PCR in the muscle where the plasmid was injected," investigators in Japan report.
"Furthermore, beta-gal expression was detected in the same muscle sample by beta-gal staining," said...
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Source: Gene Therapy Weekly (2004-06-24)
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