Published in Gene Therapy Weekly, June 24th, 2004
"An important feature of gene-directed enzyme-prodrug therapy is that prodrug activation can provide diffusible cytotoxic metabolites capable of generating a local bystander effect in tumors. Activation of the aziridinyl dinitrobenzamide CB 1954 by E. coli nitroreductase (NTR) provides a bystander effect assumed to be due to the potently cytotoxic 4-hydroxylamine metabolite," scientists in New Zealand report.
"We show that there are four cytotoxic extracellular metabolites of CB 1954 in cultures of NTR-expressing tumor cells (the 2- and 4-hydroxylamines and...
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