Published in Gene Therapy Weekly, June 24th, 2004
According to published research from Japan, "Effective gene therapy depends on the efficient transfer of therapeutic genes to target cells. None of the current technologies, however, satisfy all of the requirements necessary for gene therapy, because the plasma and nuclear membranes of mammalian cells are tight barriers against gene transfer using synthetic delivery systems. The protein transduction domain (PTD) of human immunodeficiency virus type I (HIV-1) Tat protein greatly facilitates protein transfer via membrane destabilization."
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