Gene Transfer
High-capacity hybrid viral vectors garner transduction stability
Published in Gene Therapy Weekly, June 24th, 2004
"Viral vectors with high cloning capacity and host chromosomal integration ability are in demand for the efficient and permanent genetic modification of target cells with large DNA molecules.
"We have generated a hybrid gene transfer vehicle consisting of recombinant adeno-associated virus (AAV) replicative intermediates packaged in adenovirus (Ad) capsids. This arrangement allows cell cycle-independent nuclear delivery of recombinant AAV genomes with lengths considerably above the maximum size (i.e., 4.7 kb) that can be accommodated within AAV capsids," researchers in the Netherlands...
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Source: Gene Therapy Weekly (2004-06-24)
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