Neuroscience
Retrovirally mediated gas1 expression restricts glioma cell proliferation
Published in Gene Therapy Weekly, June 24th, 2004
"We recently reported that the targeted expression of growth arrest specific 1 (Gas1) induces apoptosis in glioma cells. Because the vast majority of gliomas present genetic alterations that reduce their ability to undergo apoptosis, a gene therapy strategy aimed at reinstating apoptotic processes in glioma cells is an interesting approach for the treatment of these tumors.
"We used a retroviral gene transfer system to transduce C6 glioma cells with a transgene in which the expression of a full-length human gas1 cDNA is under the transcriptional control of a human promoter of...
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Source: Gene Therapy Weekly (2004-06-24)
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