Genetic Engineering
Stem cell factor gene-modified natural killer cells overwhelm tumor cells
Published in Gene Therapy Weekly, June 24th, 2004
According to recent research published in the journal Oncology Reports, "NK-92 cells are effective against a broad range of malignant targets both in vitro and in vivo. Stem cell factor (SCF) is an important early acting cytokine for NK cell development. The characterization and implication in clinic of SCF gene-modified NK-92 cells need to be investigated."
"SCF cDNA was inserted into pcDNA3 eukaryotic expression vector and the recombinant vector (pcDNA3-SCF) was transfected into NK-92 cells. The SCF gene-modified NK-92 cells (NK92-SCF) were cloned and characterized by...
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Source: Gene Therapy Weekly (2004-06-24)
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