Ribosome
Decreased repeat lengths encourage transgene stability after transfection
Published in Gene Therapy Weekly, June 24th, 2004
According to published research from Denmark, "retroviral vectors that are able to sustain multiple rounds of replication may find many applications. However, one critical feature of such vectors is the ability to maintain an intact transgene cassette during repeated rounds of replication. We here report on the stability of a translational cassette consisting of an internal ribosome entry site followed by the enhanced green fluorescent protein coding sequence inserted in different configurations into murine leukemia virus genomes."
"In two of the constructs, the insert was...
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Source: Gene Therapy Weekly (2004-06-24)
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