Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . July 1st, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Drug Resistance - Downregulated Bcl-2 or xIAP enhances the efficacy of breast cancer chemotherapy
Gastroenterology - Aurora-2 is a potential target for the treatment of pancreatic cancer
Genetic Engineering - Administration route shapes the effects of IL-12-expressing dendritic cells
Geriatrics - Plasmid-based hormone therapy could improve disease or age-induced wasting
Vector Development - Folate receptors ensure correct delivery of tumor-selective gene therapy
Awards - Doctor named young investigator of the year by gene therapy society
Bacteria - Viral Antigens enters strategic collaboration
Biotechnology - Experts warn that gene research could be used for warfare
Blood Vessel - Company announces new intravenous gene-delivery method
Breast Cancer - Survivin, Bcl-2, p53 and bax expression increased in breast carcinoma
Business Update - Company begins operation of 2500-liter bioreactor
Cancer Therapy - ADVEXIN and INGN 241 featured at international scientific conference
Cancer Therapy - Endothelial cell-specific human antibodies might retard tumor growth
Cancer Therapy - Gene therapy tested to protect bone marrow during chemotherapy
Carcinoma - Bcl-2 expression decreases in endometrial carcinomas
Collaborations - Company begins exploratory collaboration with Novartis Institutes
Colorectal Cancer - Alternative genetic pathway to human colorectal cancer found
Colorectal Cancer - Cytochrome C depletion intensifies the immunogenicity of colon cancer cells
DNA Manufacturing - Company announces DNA fermentation breakthrough
Endocrinology - Hypothalamic glutamate decarboxylase expression cuts rodent feeding behavior
Gene Therapy - New research on the progress of gene therapy presented at meeting
Gene Transfer - A new quantitative method measures the magnitude and volume of transgenes
Gene Transfer - NK4 transfection generates several modes of antitumor activity
Genetics - Company adds cell-based knockins to its vector application services
Genetics - Human Genome Project looks beyond man
Genomics - Pharmacogenomic profiling of PI3K/PTEN-AKT-mTOR pathway in tumors elucidated
Geriatrics - New research hints at genetic changes in brains that could explain aging
Growth-Hormone Deficiency - Companies agree to discontinue commercialization of Nutropin Depot
Gynecology - Bikunin plus paclitaxel trims tumor burden and ascites in ovarian cancer models
HIV/AIDS - RNAi is gene-specific therapeutic option to control HIV-1 replication
HIV/AIDS Genetics - Mutations at position 184 of HIV-1 RT affect virus titer and viral DNA synthesis
HIV/AIDS Research - Major 5' site mutation renders CMV-driven HIV-1 proviral clone Tat-dependent
HIV/AIDS Treatment - Vif-resistant mutant APOBEC3G may provide gene therapy approach to HIV infection
Hemophilia - Foundation says it's not deterred by Avigen gene-transfer therapy announcement
Hepatitis C Vaccine - Vaccine encoding hepatitis C antigens elicits specific immune response
Immunology - Cell-line company adds Dr. Stephen Chang to scientific advisory board
Immunology - Dendritic cells made to overexpress CCL21 stimulate tumor immunity
Immunology - Long-term effects seen after exposure to TCDD contamination
Immunology - NIH awards phase II SBIR to develop zebrafish apoptosis drug-screening assays
Immunology - Results on electroporation-enhanced DNA vaccine delivery presented at meeting
Immunotherapy - Lorus announces European patent to protect unique tumor suppressor
Incontinence - Recombinant IGF-1 gene therapy may improve nerve structure, function recovery
Ischemic Stroke - Post-ischemic neurotrophic factor gene transfer prevents delayed neuronal death
Patents - Gene therapy may be useful in cancer treatments
Personnel - Dr. Michael Fons tapped as executive director, corporate development
Personnel - Katherine High named president of gene therapy group
Receptor Studies - Hapten receptors bear selective delivery of imaging and therapeutic agents
Restenosis - Ultrasound-augmented nucleotide transfer harnesses neointimal growth
Stem-Cell Research - BCR-ABL has distinct biological effects in primary human hematopoietic cells
Transduction - Electric field-induced molecular vibration forges DNA transfer
Tumor Suppression - Modified thrombospondin-2 cDNA transduction stops tumor growth and angiogenesis
Vector Development - Hybrid LTR retroviruses seek and transfect tumor endothelial cells
Vector Development - PLL-modified silica nanoparticles transport antisense oligonucleotides
Virology - Alternatively spliced soluble CARs inhibit coxsackievirus infection
Virology - Viral cocktails afford efficient gene transfer in animal models
Virology - pVP2 precursor C-terminal domain essential for VP2-VP3 interaction
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