Cancer Therapy
Endothelial cell-specific human antibodies might retard tumor growth
Published in Gene Therapy Weekly, July 1st, 2004
According to scientists in Germany, "we have isolated single-chain Fv fragments directed against human endothelial cells from a novel fully synthetic human scFv library (scFv 479). This library was constructed using the variable germline segments DP47 and DPkappa9 as scaffolds. Complementarity-determining regions 3 (CDR) of the variable heavy and light chain were introduced with a length of 9 amino acid residues."
"In total, 16 amino acid positions of all 6 CDRs exposed in the antigen-binding site were randomized and the library was produced from synthetic oligonucleotides encoding...
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Source: Gene Therapy Weekly (2004-07-01)
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