HIV/AIDS
RNAi is gene-specific therapeutic option to control HIV-1 replication
Published in Gene Therapy Weekly, July 1st, 2004
"Small interfering RNAs (siRNAs) have been shown to direct sequence-specific inhibition of gene expression in mammalian cells. siRNAs are RNA duplexes of 21-23 nucleotides (nts) with approximately 2nt 3' overhangs that can induce degradation of their homologous target mRNAs without interferon responses in mammalian cells.
"The degradation of the target occurs at the post-transcriptional level, meaning a post-transcriptional gene silencing (PTGS) mechanism called as RNA interference (RNAi)," researchers in the United States report.
"RNAi has emerged as an...
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Source: Gene Therapy Weekly (2004-07-01)
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