Genetic Engineering
Administration route shapes the effects of IL-12-expressing dendritic cells
Published in Gene Therapy Weekly, July 1st, 2004
According to published research from the United States, "gene-modified dendritic cells (DC) provide unique therapeutic strategies for prostate cancer; however, the comparative evaluation of specific delivery options using appropriate preclinical models has not been described. In this study, bone marrow-derived DC were genetically engineered to express high levels of interleukin-12 (IL-12) with or without the costimulatory molecule B7-1, by ex vivo infection with recombinant adenoviral vectors."
"We used an orthotopic metastatic mouse prostate cancer preclinical model (178-2...
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Source: Gene Therapy Weekly (2004-07-01)
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