Restenosis
Ultrasound-augmented nucleotide transfer harnesses neointimal growth
Published in Gene Therapy Weekly, July 1st, 2004
According to recent research from Japan, "since restenosis after angioplasty still remains a major clinical problems, inhibition of neointimal formation is an important subject. In this study, we focused on the transcription factor, E2F, that plays a pivotal role in the transactivation of cell-cycle regulatory genes, and also we developed a new delivery system of decoy oligodeoxynucleotides (ODN)."
"We transfected E2F decoy ODN mixed with an echo-contrast microbubble agent (Optison) into rat carotid artery balloon-injured model by using therapeutic ultrasound (US) to inhibit...
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Source: Gene Therapy Weekly (2004-07-01)
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