Breast Cancer

ER- breast cancer cell ERa re-expression recreate hormone-responsive phenotype

Published in Gene Therapy Weekly, July 8th, 2004

Estrogen receptor negative breast cancer cell ERalpha re-expression recreate a hormone-responsive phenotype.

"Estrogen receptor (ER)-negative breast carcinomas are often difficult to treat with antiestrogens. This work was performed to determine if the re-expression of the human ERalpha could restore the hormone response of these cells. We have transfected the human wild-type ERalpha to an ER-negative breast cancer cell line (MDA-MB-231) using a tetracycline-regulated gene expression system," investigators in Mexico reported.

"We obtained a new cell line, MDA-A4-5/2. Cell count and flow cytometry ''S'' phase cell fraction showed that...

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Source: Gene Therapy Weekly (2004-07-08)

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