Drug Development
Lipid optimization augments solid lipid nanoparticle-mediated gene transfer
Published in Gene Therapy Weekly, July 8th, 2004
According to a study from Germany, "this investigation is focused on the enhancement of in vitro transfection activity by optimizing cationic lipid and matrix lipid composition of solid lipid nanoparticles (SLN). For this purpose SLN were formulated by using two different matrix lipids and six different cationic detergents."
"These 12 formulations were tested for physical parameters such as particle size, zeta potential and DNA-binding capacity, and also for their biological properties such as cytotoxicity and in vitro transfection efficiency," wrote K. Tabatt and...
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Source: Gene Therapy Weekly (2004-07-08)
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