Drug Development
Tumor growth stalls upon electroporation-based antiangiogenic gene transfer
Published in Gene Therapy Weekly, July 8th, 2004
"Using a nonviral, electroporation-based gene transfection approach, we demonstrate the efficient and consistent transfection of two poorly immunogenic tumor cell lines: B16F10 melanoma and renal carcinoma (RENCA). Three genes, interleukin (IL-12), angiostatin (AS), and an endostatin:angiostatin fusion protein (ES:AS) were subcloned into a DNA plasmid containing EBNA1-OriP, which was then transfected into B16F10 and RENCA cells. Significant levels of protein were secreted into the culture supernatants of transfected cells in vitro," scientists in the United States report.
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Source: Gene Therapy Weekly (2004-07-08)
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