Neuroscience
Gene knockdown ameliorates parkinsonian motor symptoms in study animals
Published in Gene Therapy Weekly, July 8th, 2004
"The present study reported the efficacy of antisense oligonucleotides specific for N-methyl-D-aspartate receptor one (NR1) in reduction of motor symptom in a rat parkinsonian model, the unilateral 6-hydroxydopamine-lesioned rat," scientists writing in the journal Neurochemistry International report.
"Significant reductions in apomorphine-induced contralateral rotation were only seen in the NR1 antisense-treated lesioned rats (after a single intraparenchymal dose of antisense to the lesioned neostriatum; 15 nmol in 3 mcl of saline) at 1 or 2 days after the treatment. No...
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Source: Gene Therapy Weekly (2004-07-08)
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