Coronary Artery Bypass Surgery
Overexpressed p53 blocks neointima formation after vein grafting
Published in Gene Therapy Weekly, July 15th, 2004
According to recent research from the Peoples Republic of China, "patency rates for autologous saphenous vein (SV) conduits used in coronary artery bypass grafts remain poor. Patients with failed grafts are difficult to treat with subsequent interventions, necessitating the development of innovative therapies. Previous studies have suggested that induction of smooth muscle cell (SMC) apoptosis may reduce neointima formation."
"We overexpressed the proapoptotic gene p53 at the lumenal surface of SV grafts using adenoviral (Ad)-mediated gene transfer in porcine SVs prior to grafting in...
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Source: Gene Therapy Weekly (2004-07-15)
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