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Stem-Cell Research

Neuronally expressed SCF induces neural stem cell migration to brain injury site

Published in Gene Therapy Weekly, July 15th, 2004

Neuronally expressed stem cell factor induces neural stem cell migration to the brain injury site.

According to a study from the United States, "Neural stem/progenitor cell (NSPC) migration toward sites of damaged central nervous system (CNS) tissue may represent an adaptive response for the purpose of limiting and/or repairing damage. Little is known of the mechanisms responsible for this migratory response."

"We constructed a cDNA library of injured mouse fore-brain using subtractive suppression hybridization (SSH) to identify genes that were selectively upregulated in the injured hemisphere.

"We demonstrate that stem cell...

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