Amyotrophic Lateral Sclerosis

Lentiviral delivery of growth factor prolongs the lives of murine ALS models

Published in Gene Therapy Weekly, July 15th, 2004

Lentiviral delivery of growth factor prolongs the lives of murine ALS models.

"Amyotrophic lateral sclerosis (ALS) causes adult-onset, progressive motor neuron degeneration in the brain and spinal cord, resulting in paralysis and death 3 to 5 years after onset in most patients. ALS is still incurable, in part because its complex etiology remains insufficiently understood," according to scientists in England.

"Recent reports have indicated that reduced levels of vascular endothelial growth factor (VEGF), which is essential in angiogenesis and has also been implicated in neuroprotection, predispose mice and humans to ALS," wrote M. Azzouz and...

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Source: Gene Therapy Weekly (2004-07-15)

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