Drug Development
Atelocollagen leads small interfering RNA to vascular growth factor
Published in Gene Therapy Weekly, July 22nd, 2004
According to a study from Japan, "vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer."
"We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer cell line, PC-3, whereas the control scramble siRNA showed no effects," said Y. Takei and colleagues, Nagoya University, Graduate School of Medicine.
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Source: Gene Therapy Weekly (2004-07-22)
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