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Gene Transfer

Branched polymer guides plasmids into brain-derived cells

Published in Gene Therapy Weekly, July 22nd, 2004

Branched polymer guides plasmids into brain-derived cells.

"The introduction of effective transfection reagents has had a dramatic impact on basic scientific studies over the past decade and is methodically becoming a clinical relevant agent. An area where these agents have had little impact to date is in transfection of neuronal cells either in vivo or in vitro. The poor results, obtained with these cells, likely arise from the innate properties of the cell itself such as its post-mitotic state and its fragility to the transfection agent," scientists in the United States report.

"In this report, we investigated the transfection efficiency of...

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